Programmed Cell Death in Parkinson's Disease
Identifieur interne : 001146 ( Main/Exploration ); précédent : 001145; suivant : 001147Programmed Cell Death in Parkinson's Disease
Auteurs : Katerina Venderova [États-Unis] ; David S. Park [Canada]Source :
- Cold Spring Harbor Perspectives in Medicine [ 2157-1422 ] ; 2012.
Abstract
Parkinson's disease is a debilitating disorder characterized by a progressive loss of dopaminergic neurons caused by programmed cell death. The aim of this review is to provide an up-to-date summary of the major programmed cell death pathways as they relate to PD. For a long time, programmed cell death has been synonymous with apoptosis but there now is evidence that other types of programmed cell death exist, such as autophagic cell death or programmed necrosis, and that these types of cell death are relevant to PD. The pathways and signals covered here include namely the death receptors, BCL-2 family, caspases, calpains, cdk5, p53, PARP-1, autophagy, mitophagy, mitochondrial fragmentation, and parthanatos. The review will present evidence from postmortem PD studies, toxin-induced models (especially MPTP/MPP+, 6-hydroxydopamine and rotenone), and from
Url:
DOI: 10.1101/cshperspect.a009365
PubMed: 22908196
PubMed Central: 3405826
Affiliations:
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Park</name><affiliation wicri:level="1"><nlm:aff id="af2">Department of Cellular Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Cellular Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5</wicri:regionArea><wicri:noRegion>Ontario K1H 8M5</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22908196</idno><idno type="pmc">3405826</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405826</idno><idno type="RBID">PMC:3405826</idno><idno type="doi">10.1101/cshperspect.a009365</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000B80</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B80</idno><idno type="wicri:Area/Pmc/Curation">000B80</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B80</idno><idno type="wicri:Area/Pmc/Checkpoint">000778</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000778</idno><idno type="wicri:Area/Ncbi/Merge">001223</idno><idno type="wicri:Area/Ncbi/Curation">001223</idno><idno type="wicri:Area/Ncbi/Checkpoint">001223</idno><idno type="wicri:Area/Main/Merge">001168</idno><idno type="wicri:Area/Main/Curation">001146</idno><idno type="wicri:Area/Main/Exploration">001146</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Programmed Cell Death in Parkinson's Disease</title><author><name sortKey="Venderova, Katerina" sort="Venderova, Katerina" uniqKey="Venderova K" first="Katerina" last="Venderova">Katerina Venderova</name><affiliation wicri:level="2"><nlm:aff id="af1">University of the Pacific, Thomas J. Long School of Pharmacy, Department of Physiology and Pharmacology, Stockton, California 95211</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of the Pacific, Thomas J. Long School of Pharmacy, Department of Physiology and Pharmacology, Stockton</wicri:cityArea></affiliation></author><author><name sortKey="Park, David S" sort="Park, David S" uniqKey="Park D" first="David S." last="Park">David S. Park</name><affiliation wicri:level="1"><nlm:aff id="af2">Department of Cellular Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Cellular Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5</wicri:regionArea><wicri:noRegion>Ontario K1H 8M5</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cold Spring Harbor Perspectives in Medicine</title><idno type="eISSN">2157-1422</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Parkinson's disease is a debilitating disorder characterized by a progressive loss of dopaminergic neurons caused by programmed cell death. The aim of this review is to provide an up-to-date summary of the major programmed cell death pathways as they relate to PD. For a long time, programmed cell death has been synonymous with apoptosis but there now is evidence that other types of programmed cell death exist, such as autophagic cell death or programmed necrosis, and that these types of cell death are relevant to PD. The pathways and signals covered here include namely the death receptors, BCL-2 family, caspases, calpains, cdk5, p53, PARP-1, autophagy, mitophagy, mitochondrial fragmentation, and parthanatos. The review will present evidence from postmortem PD studies, toxin-induced models (especially MPTP/MPP+, 6-hydroxydopamine and rotenone), and from <italic>α-synuclein</italic>, <italic>LRRK2, Parkin, DJ-1</italic>, and <italic>PINK1</italic> genetic models of PD, both in vitro and in vivo.</p></div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Venderova, Katerina" sort="Venderova, Katerina" uniqKey="Venderova K" first="Katerina" last="Venderova">Katerina Venderova</name></region></country><country name="Canada"><noRegion><name sortKey="Park, David S" sort="Park, David S" uniqKey="Park D" first="David S." last="Park">David S. Park</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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